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| 1838 |
| | | The Central American Federation splits into Guatemala, El Salvador, Honduras, Nicaragua and Costa Rica | |
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| 1846 |
| | | President Polk sends a US army into Texas, provoking the Mexican-American War | |
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| 1848 |
| | | A treaty signed in Guadalupe-Hidalgo, ending the Mexican-American War, gives the US six new states | |
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| 1852 |
| | | US entrepreneur Cornelius Vanderbilt conveys passengers across the American continent through Nicaragua by steamship and horse and carriage | |
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| 1855 |
| | | The Panama Railroad company completes a line between the Atlantic and the Pacific, providing America's first transcontinental link | |
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| 1855 |
| | | Liberal leaders Juan Alvarez and Ignacio Comonfort launch a political programme in Mexico that becomes know simply as 'the Reform' | |
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| 1856 |
| | | An American adventurer, William Walker, wins control of the government in Nicaragua and for a year rules as president | |
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| 1858 |
| | | Conservatives seize Mexico City at the start of a civil war against the Liberal government | |
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| 1860 |
| | | US adventurer William Walker, thrown out of Nicaragua in 1857, is executed in Honduras | |
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| 1861 |
| | | The Liberals recover Mexico City and elect Benito Juarez as president | |
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